The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Jan. 02, 2018
Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);
Bristol-myers Squibb Company, Princeton, NJ (US);
Todd Kinsella, Redwood City, CA (US);
Marina Gelman, San Francisco, CA (US);
Hui Hong, Foster City, CA (US);
Ihab S. Darwish, San Carlos, CA (US);
Rajinder Singh, Belmont, CA (US);
Jiaxin Yu, San Carlos, CA (US);
Robert M. Borzilleri, Carversville, PA (US);
Upender Velaparthi, Cheshire, CT (US);
Peiying Liu, Madison, CT (US);
Chetan Padmakar Darne, Orange, CT (US);
Hasibur Rahaman, Bangalore, IN;
Jayakumar Sankara Warrier, Bangalore, IN;
Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);
Bristol-Meyers Squibb Company, Princeton, NJ (US);
Abstract
Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, Rand R' are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-β, and can be used to treat disease by blocking TGF-β signaling.