The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 14, 2019

Filed:

Mar. 12, 2015
Applicant:

Chong Kun Dang Pharmaceutical Corp., Seoul, KR;

Inventors:

Hyeseung Song, Gyeonggi-do, KR;

Changgon Lee, Gyeonggi-do, KR;

Dalyong Kwak, Gyeonggi-do, KR;

Jaeyoung Lee, Gyeonggi-do, KR;

Suyeal Bae, Gyeonggi-do, KR;

Yuntae Kim, Gyeonggi-do, KR;

Daekwon Bae, Gyeonggi-do, KR;

Nina Ha, Gyeonggi-do, KR;

Miseon Bae, Gyeonggi-do, KR;

Jihyun Kim, Gyeonggi-do, KR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/04 (2006.01); C07D 401/06 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/10 (2006.01); C07D 403/12 (2006.01); C07D 405/06 (2006.01); C07D 405/10 (2006.01); C07D 405/12 (2006.01); C07D 409/06 (2006.01); C07D 409/10 (2006.01); C07D 413/06 (2006.01); C07D 413/10 (2006.01); A61K 31/496 (2006.01); A61K 31/5375 (2006.01);
U.S. Cl.
CPC ...
C07D 241/04 (2013.01); C07D 401/06 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 405/06 (2013.01); C07D 405/10 (2013.01); C07D 405/12 (2013.01); C07D 409/06 (2013.01); C07D 409/10 (2013.01); C07D 413/06 (2013.01);
Abstract

A compound of formula (I), having histone deacetylase 6 (HDAC6) inhibitory activity, wherein X, Q, N, R, R, L, and n are as described, isomers thereof, or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions comprising the same, a method of treating disease using the composition, and methods for preparing the novel compounds. The novel compounds according to the present invention have histone deacetylase 6 (HDAC6) inhibitory activity, and are effective for the prevention or treatment of HDAC6-associated diseases, including cancer, inflammatory diseases, autoimmune diseases, neurological diseases and neurodegenerative disorders.


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