The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Jan. 27, 2012
Applicants:
Luis Brito, Concord, MA (US);
Manmohan Singh, Cary, NC (US);
Derek O'hagan, Winchester, MA (US);
Inventors:
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/39 (2006.01); A61K 39/095 (2006.01); A61K 9/107 (2006.01); A61K 31/00 (2006.01); A61K 31/4745 (2006.01); A61K 9/00 (2006.01); A61K 31/4375 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61K 47/44 (2017.01);
U.S. Cl.
CPC ...
A61K 39/095 (2013.01); A61K 9/0019 (2013.01); A61K 9/1075 (2013.01); A61K 31/00 (2013.01); A61K 31/4375 (2013.01); A61K 31/4745 (2013.01); A61K 39/39 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/44 (2013.01);
Abstract
High loading of lipophilic pharmacological agents (in particular, lipophilic immunopotentiators) in oil-in-water emulsions can result in crystallisation of the lipophilic agent. To overcome this problem the invention uses an oil-in-water emulsion in combination with a crystallisation inhibitor, and this combination provides emulsions which can be loaded with high levels of lipophilic pharmacological agents.