The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 14, 2019

Filed:

Feb. 18, 2015
Applicant:

Children's Hospital Los Angeles, Los Angeles, CA (US);

Inventor:

Lingtao Wu, Rancho Palos Verdes, CA (US);

Assignee:

Children's Hospital Los Angeles, Los Angeles, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); A61K 31/192 (2006.01); A61K 31/196 (2006.01); A61K 35/15 (2015.01); A61K 35/12 (2015.01); A61K 45/06 (2006.01); C12N 5/0787 (2010.01); A61K 31/69 (2006.01); G01N 33/84 (2006.01);
U.S. Cl.
CPC ...
A61K 38/193 (2013.01); A61K 31/192 (2013.01); A61K 31/196 (2013.01); A61K 31/69 (2013.01); A61K 35/15 (2013.01); A61K 45/06 (2013.01); C12N 5/0642 (2013.01); G01N 33/84 (2013.01); A61K 2035/124 (2013.01); C12N 2501/22 (2013.01); G01N 2800/52 (2013.01);
Abstract

The invention relates methods of using a retinoid agonist and a G-CSF or an analog thereof to treat, prevent, reduce the likelihood of having, reduce the severity of and/or slow the progression of a condition in a subject. The retinoid agonist and the G-CSF or the analog thereof may be provided in a single composition or in separate compositions. A therapeutically effective amount of the retinoid agonist and the G-CSF or the analog thereof may be administered to the subject concurrently or sequentially. Conditions treatable with the methods and compositions include but are not limited to various forms of neutropenia and microbial infections. The invention also relates to methods for determining the efficacy of the treatments described herein.


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