The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Apr. 20, 2018
Applicants:
Chang Gung University, Tao-Yuan, TW;
Chiayi Chang Gung Memorial Hospital, Chiayi County, TW;
Inventors:
Assignees:
CHANG GUNG UNIVERSITY, Tao-Yuan, TW;
CHIAYI CHANG GUNG MEMORIAL HOSPITAL, Chiayi County, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 31/519 (2006.01); A61K 31/12 (2006.01); A61K 31/352 (2006.01); A61K 31/555 (2006.01); A61K 31/7088 (2006.01); C12N 15/113 (2010.01); A61P 19/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/12 (2013.01); A61K 31/352 (2013.01); A61K 31/555 (2013.01); A61K 31/7088 (2013.01); A61P 19/10 (2018.01); C12N 15/1137 (2013.01); C12N 2310/14 (2013.01);
Abstract
Disclosed herein is a method of preventing and/or treating abnormal bone resorption and/or osteoporosis in a subject in need thereof. The method comprises administering to the subject an effective amount of an inhibitor on inhibiting neddylation. According to some embodiments of the present disclosure, the inhibitor on inhibiting neddylation is a NAE inhibitor, which includes but is not limited to, MLN4924.