The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Mar. 31, 2016
National University Corporation Okayama University, Okayama-shi, Okayama, JP;
Hiroki Kakuta, Okayama, JP;
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, Okayama-Shi, Okayama, JP;
Abstract
There is provided a pharmaceutical composition for treatment or prevention of a neurodegenerative disease, comprising an RXR agonist as an active ingredient, which is a compound represented by formula (1) or (2). The pharmaceutical composition is effective in treatment or prevention of neurodegenerative diseases such as dementia, Parkinson's disease and multiple sclerosis with reducing side effects such as enlargement of the liver and elevation of blood triglyceride level. In these formulas, A represents CMe, N-methyl, N-ethyl or N-isopropyl; X represents N, CH or C—CF; Y and Z represent N or CH; Rrepresents methyl, hydroxy, methoxy or ethoxy; Rrepresents H, methyl or ethyl; B represents NRor CHR; Rrepresents alkyl; and Rrepresents H, halogen, alkyl, alkenyl, aryl, alkynyl, alkoxy or acyl.