The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Nov. 29, 2017
Applicant:
The Trustees of Princeton University, Princeton, NJ (US);
Inventors:
Bonnie L. Bassler, Princeton, NJ (US);
Lark J. Perez, Ewing, NJ (US);
Martin F. Semmelhack, Princeton, NJ (US);
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY, Princeton, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/333 (2006.01); A61K 45/06 (2006.01); A61K 31/401 (2006.01); A61K 31/53 (2006.01); A01N 43/36 (2006.01);
U.S. Cl.
CPC ...
A61K 31/401 (2013.01); A01N 43/36 (2013.01); A61K 31/53 (2013.01); A61K 45/06 (2013.01); C07D 207/333 (2013.01); Y02A 50/471 (2018.01);
Abstract
A structurally distinct and potent series of synthetic small molecule activators ofquorum sensing have been chemically synthesized. The small molecule activators reduce virulence in. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.