The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Dec. 02, 2011
Steven Bloembergen, Okemos, MI (US);
Ian J. Mclennan, Burlington, CA;
Nathan Jones, Hamilton, CA;
Ryan Wagner, Kitchener, CA;
Aareet Krsna Ganesh Shermon, Waterloo, CA;
Abdel Rahman Elsayed, Waterloo, CA;
Juewen Liu, Kitchener, CA;
Steven Bloembergen, Okemos, MI (US);
Ian J. McLennan, Burlington, CA;
Nathan Jones, Hamilton, CA;
Ryan Wagner, Kitchener, CA;
Aareet Krsna Ganesh Shermon, Waterloo, CA;
Abdel Rahman Elsayed, Waterloo, CA;
Juewen Liu, Kitchener, CA;
GreenMark Biomedical Inc., East Lansing, MI (US);
Abstract
A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.