The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2019
Filed:
Feb. 09, 2015
Almac Diagnostics Limited, Craigavon, GB;
Denis Paul Harkin, Dromore, GB;
Richard Kennedy, Belfast, GB;
Katherine E. Keating, Magherafelt, GB;
Andrena McCavigan, Derryadd Lurgan, GB;
Laura A. Hill, Lisburn, GB;
Steve Deharo, Belfast, GB;
Timothy Davison, Hillsborough, GB;
Fionnuala Patterson, Hauxton, GB;
Sinead Donegan, Belfast, GB;
Gera Jellema, Portadown, GB;
Charlie Gourley, Dumfermline, GB;
Almac Diagnostics Limited, Craigavon, GB;
Abstract
Methods for selecting whether to administer an anti-angiogenic therapeutic agent to a subject include steps of measuring the expression levels of one or more biomarkers selected from Table 2 or Table 3 in a sample from the subject; assessing from the expression levels of the one or more biomarkers whether the sample from the subject is positive or negative for a biomarker signature, wherein if the sample is positive for the biomarker signature an anti-angiogenic therapeutic agent is contraindicated. Related prognostic methods and treatment methods are also provided. The invention is particularly applicable in ovarian and colorectal cancers.