The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2019
Filed:
May. 08, 2015
Applicant:
Université Laval, Québec, CA;
Inventors:
Jacques P. Tremblay, Stoneham et Tewkesbury, CA;
Joël Rousseau, Québec, CA;
Pierre Chapdelaine, Lévis, CA;
Assignee:
UNIVERSITÉ LAVAL, Québec, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 15/113 (2010.01); C07K 14/47 (2006.01); C12N 9/22 (2006.01); C12N 15/63 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C07K 14/4711 (2013.01); C12N 9/22 (2013.01); C12N 15/102 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C12N 15/63 (2013.01); C12N 2310/10 (2013.01); C12N 2310/20 (2017.05);
Abstract
Methods and products are described related to use of the CRISPR/Cas9 system to introduce a modification into an APP gene, such as guide RNAs and recombinant proteins, for decreasing amyloid beta peptide produced by a cell. Also described are uses of such methods and products for the treatment of Alzheimer's disease and/or age-related cognitive decline in a cell from a subject in need thereof.