The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 07, 2019

Filed:

Mar. 14, 2017
Applicant:

The Regents of the University of Colorado, a Body Corporate, Denver, CO (US);

Inventor:

Jan P. Kraus, Littleton, CO (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/88 (2013.01); A61K 38/00 (2013.01); C12Y 402/01022 (2013.01);
Abstract

Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologs are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.


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