The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2019
Filed:
Jul. 13, 2015
Applicant:
Medshine Discovery Inc., Nanjing, Jiangsu, CN;
Inventors:
Chun Sing Li, Shanghai, CN;
Jian Li, Shanghai, CN;
Yong Cang, Shanghai, CN;
Shuhui Chen, Shanghai, CN;
Gang Li, Shanghai, CN;
Xiongbin Xu, Shanghai, CN;
Lun Lu, Shanghai, CN;
Assignee:
MEDSHINE DISCOVERY INC., Jiangsu, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/3015 (2013.01); A61K 47/6803 (2017.08); A61K 47/6817 (2017.08); A61K 47/6851 (2017.08); A61K 47/6855 (2017.08); A61K 47/6889 (2017.08); C07K 16/2863 (2013.01); C07K 2317/24 (2013.01);
Abstract
The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.