The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 07, 2019

Filed:

Mar. 16, 2016
Applicants:

Chromadex Inc., Irvine, CA (US);

The Queen's University of Belfast, Belfast, GB;

Inventors:

Ryan Dellinger, Azusa, CA (US);

Marie Eugenie Migaud, Lurgan, GB;

Philip Redpath, Portadown, GB;

Troy Rhonemus, Mission Viejo, CA (US);

Richard Cunningham, Portadown, GB;

Assignees:

ChromaDex, Inc., Irvine, CA (US);

The Queen's University of Belfast, Belfast, IE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/048 (2006.01); A61Q 19/08 (2006.01); A61Q 19/00 (2006.01); A61K 8/67 (2006.01);
U.S. Cl.
CPC ...
C07H 19/048 (2013.01); A61K 8/675 (2013.01); A61Q 19/00 (2013.01); A61Q 19/08 (2013.01); A61Q 19/004 (2013.01); A61Q 19/007 (2013.01);
Abstract

Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2',3′,5′-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2′,3′,5′-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.


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