The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2019
Filed:
May. 12, 2016
Applicant:
Alfasigma S.p.a., Milan, IT;
Inventors:
Paola Maffei, Bologna, IT;
Milena Bachetti, Bologna, IT;
Giuseppe Bottoni, Bologna, IT;
Giuseppe Claudio Viscomi, Bologna, IT;
Assignee:
ALFASIGMA S.P.A., Milan (MI), IT;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 491/22 (2006.01); A61K 9/20 (2006.01); A61K 9/50 (2006.01); A61K 31/437 (2006.01); A61K 47/10 (2017.01); A61K 47/26 (2006.01); A61K 9/16 (2006.01); A61K 9/28 (2006.01);
U.S. Cl.
CPC ...
C07D 491/22 (2013.01); A61K 9/1617 (2013.01); A61K 9/1623 (2013.01); A61K 9/1652 (2013.01); A61K 9/2013 (2013.01); A61K 9/2054 (2013.01); A61K 9/2081 (2013.01); A61K 9/28 (2013.01); A61K 9/501 (2013.01); A61K 9/5015 (2013.01); A61K 9/5026 (2013.01); A61K 31/437 (2013.01); A61K 47/10 (2013.01); A61K 47/26 (2013.01); C07B 2200/13 (2013.01);
Abstract
Polyols stabilize polymorphous form of rifaximin, in particular the β form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph β is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.