IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10280145 B1

PDFFull Text
Date of Patent:
May. 07, 2019

Filed:

Aug. 31, 2016

Urea derivative and use therefor

Applicant:

Toray Industries, Inc., Tokyo, JP;

Inventors:

Yukihiro Nishio, Kamakura, JP;

Yuko Kubota, Kamakura, JP;

Masashi Yamamoto, Kamakura, JP;

Yutaka Nishimura, Kamakura, JP;

Tomohide Masuda, Kamakura, JP;

Hideyuki Tsutsui, Otsu, JP;

Keiichi Okimura, Kamakura, JP;

Syuji Udagawa, Kamakura, JP;

Mie Kaino, Kamakura, JP;

Hiroyuki Meguro, Kamakura, JP;

Yumiko Sekiya, Otsu, JP;

Assignee:

Toray Industries, Inc., , JP;

Attorney:

DLA Piper LLP (US)

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 239/47 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); A61K 31/17 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/4545 (2006.01); A61K 31/50 (2006.01); A61K 31/506 (2006.01); A61K 31/513 (2006.01); A61K 31/5377 (2006.01); C07D 213/74 (2006.01); C07C 275/34 (2006.01); C07D 401/04 (2006.01); C07D 237/14 (2006.01); C07D 239/34 (2006.01); C07D 405/12 (2006.01); C07D 213/30 (2006.01); C07D 213/65 (2006.01);
U.S. Cl.
CPC ...
C07D 239/47 (2013.01); A61K 31/17 (2013.01); A61K 31/4406 (2013.01); A61K 31/4409 (2013.01); A61K 31/4427 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/50 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 31/5377 (2013.01); C07C 275/34 (2013.01); C07D 213/30 (2013.01); C07D 213/65 (2013.01); C07D 213/74 (2013.01); C07D 237/14 (2013.01); C07D 239/34 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01);
Abstract

A compound has inhibitory activity on Discoidin Domain Receptor 1. A urea derivative is represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein, Ris trifluoromethyl, trifluoromethoxy, or pentafluorosulfanyl; each Ris independently a hydrogen atom or methyl which is optionally substituted by one hydroxyl or one saturated heterocyclyl having four to six ring-forming atoms; Ris a hydrogen atom, halogen atom, C-Calkyl, saturated heterocyclyl having four to six ring-forming atoms and optionally having an oxo group, or RO—; and Ris phenyl, pyridyl, pyridazinyl, or pyrimidinyl, which phenyl, pyridyl, pyridazinyl, or pyrimidinyl is optionally substituted by one R.

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