The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2019
Filed:
Aug. 03, 2015
Applicant:
The Regents of the University of Colorado, a Body Corporate, Denver, CO (US);
Inventors:
Nirmal Kumar Banda, Aurora, CO (US);
V. Michael Holers, Denver, CO (US);
Assignee:
The Regents of the University of Colorado, a body corporate, Denver, CO (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 39/00 (2006.01); A61K 47/68 (2017.01); C07K 16/28 (2006.01); A61K 39/395 (2006.01); C12N 15/113 (2010.01); A61K 31/7088 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7088 (2013.01); A61K 9/0019 (2013.01); A61K 39/3955 (2013.01); A61K 47/6807 (2017.08); A61K 47/6849 (2017.08); C07K 16/2896 (2013.01); C12N 15/113 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C12N 2310/14 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3513 (2013.01); C12N 2320/32 (2013.01);
Abstract
The disclosure provides compositions and methods relating to the treatment of pain, such as pain from rheumatoid arthritis. By creating conjugates of antibodies that target C5aR and siRNA's that target C5 expression, a dual mode therapeutic that targets two different aspects of C5's inflammatory signaling.