The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2019
Filed:
Mar. 03, 2016
Applicant:
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Pudong, Shanghai, CN;
Inventors:
Fajun Nan, Shanghai, CN;
Boliang Li, Shanghai, CN;
Yang Zhan, Shanghai, CN;
Xiaowei Zhang, Shanghai, CN;
Ying Xiong, Shanghai, CN;
Xichan Hu, Shanghai, CN;
Yangming Zhang, Shanghai, CN;
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4433 (2006.01); C07D 493/04 (2006.01); A61K 31/352 (2006.01); C07B 37/04 (2006.01); C07B 49/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4433 (2013.01); A61K 31/352 (2013.01); C07D 493/04 (2013.01); C07B 37/04 (2013.01); C07B 49/00 (2013.01);
Abstract
The present invention relates to a series of analogs of natural product Pyripyropene A represented by general formula I and a preparation method and use thereof. More particularly, the present invention relates to analogs of the natural product Pyripyropene A, a preparation method and use thereof as the acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors for the treatment of cardiovascular diseases such as atherosclerosis and the like.