The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2019
Filed:
Sep. 17, 2015
Universté DE Montréal, Montréal, Québec, CA;
British Columbia Cancer Agency Branch, Vancouver, British Columbia, CA;
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Guy Sauvageau, Montréal, CA;
Keith Richard Humphries, Vancouver, CA;
Hans-Peter Kiem, Seattle, WA (US);
Iman Fares, Montréal, CA;
Jalila Chagraoui, Montréal, CA;
UNIVERSITE DE MONTREAL, Montreal, Quebec, CA;
BRITISH COLUMBIA CANCER AGENCY BRANCH, Vancouver, British Columbia, CA;
FRED HUTCHINSON CANCER RESEARCH CENTER, Seattle, WA (US);
Abstract
Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5-b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described.