The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2019
Filed:
Jul. 26, 2012
Pascale Bouillé, Escalquens, FR;
Hélène Vergnault, Toulouse, FR;
Régis Gayon, Ramonville Saint Agne, FR;
Yohann Moal, Toulouse, FR;
Pascale Bouillé, Escalquens, FR;
Hélène Vergnault, Toulouse, FR;
Régis Gayon, Ramonville Saint Agne, FR;
Yohann Moal, Toulouse, FR;
Vectalys SAS, Toulouse, FR;
Abstract
The present invention provides viral vector compositions of high titer and purity, as well as methods for production of said compositions. The methods of the invention incorporate multiple features, such as production of viral vector particles in serum free media and multiple harvesting steps following transduction of the producer cell which provides for enhanced production of said viral vectors. The viral vector compositions of the invention, by virtue of their high titer and purity, minimize the deleterious phenotypic changes that typically occur following transduction of target cells, such as loss of a sub-populations of transduced cells, and effects on proliferation, differentiation, reprogramming or functionality of transduced cells.