The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 30, 2019

Filed:

Aug. 26, 2016
Applicant:

Emulate, Inc., Boston, MA (US);

Inventors:

Daniel Levner, Brookline, MA (US);

Josiah Daniel Sliz, Boston, MA (US);

Christopher David Hinojosa, Cambridge, MA (US);

Guy Robert Thompson, II, Watertown, MA (US);

Petrus Wilhelmus Martinus van Ruijven, Glen Waverley, AU;

Matthew Daniel Solomon, Hughesdale, AU;

Christian Alexander Potzner, Port Melbourne, AU;

Patrick Sean Tuohy, St. Kilda, AU;

Joshua Gomes, Somerville, MA (US);

Norman Wen, West Roxbury, MA (US);

Jacob Freake, Somerville, MA (US);

Doug Sabin, Woburn, MA (US);

Assignee:

EMULATE, Inc., Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/34 (2006.01); C12M 1/36 (2006.01); A01N 1/02 (2006.01); C12M 3/06 (2006.01); B01L 3/00 (2006.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12N 5/071 (2010.01); C12M 3/00 (2006.01); B01L 9/00 (2006.01);
U.S. Cl.
CPC ...
C12M 23/16 (2013.01); A01N 1/021 (2013.01); A01N 1/0247 (2013.01); B01L 3/50273 (2013.01); B01L 3/502707 (2013.01); B01L 3/502715 (2013.01); B01L 3/502738 (2013.01); B01L 9/527 (2013.01); C12M 21/08 (2013.01); C12M 23/38 (2013.01); C12M 23/40 (2013.01); C12M 23/42 (2013.01); C12M 29/10 (2013.01); C12M 35/04 (2013.01); C12M 41/40 (2013.01); C12M 41/48 (2013.01); C12N 5/0602 (2013.01); B01L 2200/025 (2013.01); B01L 2200/027 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/123 (2013.01); B01L 2300/14 (2013.01); B01L 2300/161 (2013.01); B01L 2300/165 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/06 (2013.01); C12N 2521/00 (2013.01);
Abstract

The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. The invention further relates to a drop-to-drop connection scheme for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.


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