The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2019
Filed:
Sep. 11, 2017
Biocerox Products B.v., GJ Almere, NL;
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Petrus Johannes Simons, Almere, NL;
Louis Boon, Almere, NL;
Jinquan Luo, Spring House, PA (US);
Randall Brezski, Spring House, PA (US);
Monica Goldberg, Spring House, PA (US);
Biocerox Products B.V., Almere, NL;
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Abstract
The invention provides antibodies that specifically bind to human CD134. Anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). Humanized anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment.