The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2019
Filed:
Dec. 22, 2017
President and Fellows of Harvard College, Cambridge, MA (US);
Matthew D. Shair, Lexington, MA (US);
Henry Efrem Pelish, Newton, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
Compounds of Formula (A'), (B′), (C′), (D′), (E′), (A″), (B″), (C″), (D″), (E″), (G1), and (G2) are useful as therapeutics for treating a wide variety of conditions in a host such as a human, e.g., including but not limited to, conditions associated with angiogenesis and/or which are mediated by CDK8 and/or CDK19 kinase activity. Also provided are methods of modulating the β-catenin pathway, methods of modulating STAT1 activity, methods of modulating the TGFβ/BMP pathway, methods of modulating HIF-1-alpha activity in a cell, and methods of increasing BIM expression to induce apoptosis, using an effective amount of a compound of Formula (A′), (B′), (C′), (D′), (E′), (A″), (B″), (C″), (D″), (E″), (G1), or (G2).