The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 30, 2019

Filed:

Nov. 09, 2017
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Luc J. Farmer, Montreal, CA;

Michael John Boyd, Sharon, MA (US);

Dean Shannon, Richibucto Road, CA;

Michael Waldo, Grafton, MA (US);

Kwame W. Nti-Addae, Tewksbury, MA (US);

Yuegang Zhang, Wayland, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/506 (2006.01); A61K 31/4965 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/4965 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07B 2200/13 (2013.01);
Abstract

Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: include Hydrate 2 of Compound (1), Hydrate 3 of Compound (1), Form A of Compound (1), Form B of Compound (1), Form C of Compound (1), Form D of Compound (1), and amorphous Compound (1). Such polymorphic forms are useful for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.


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