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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10273228 B1

PDFFull Text
Date of Patent:
Apr. 30, 2019

Filed:

Apr. 15, 2016

Hepatitis b viral assembly effectors

Applicant:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Inventors:

Lee Daniel Arnold, Bloomington, IN (US);

Hans Maag, Kleines Wiesental, DE;

William W. Turner, Jr., Bloomington, IN (US);

Assignees:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Assembly Biosciences, Inc., Carmel, IN (US);

Attorney:

Faegre Baker Daniels LLP

Primary Examiner:

Yevgeny Valendrod

Int. Cl.
CPC ...
C07D 403/14 (2006.01); C07D 401/04 (2006.01); C07D 403/12 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 239/42 (2006.01); C07D 239/48 (2006.01); C07D 409/12 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 401/14 (2006.01); C07D 417/14 (2006.01); C07D 213/74 (2006.01); C07D 239/47 (2006.01); C07D 413/04 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61P 31/20 (2006.01);
U.S. Cl.
CPC ...
C07D 403/14 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61P 31/20 (2018.01); C07D 213/74 (2013.01); C07D 239/42 (2013.01); C07D 239/47 (2013.01); C07D 239/48 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 409/12 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01);
Abstract

Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.

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