IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10273222 B1

PDFFull Text
Date of Patent:
Apr. 30, 2019

Filed:

Jun. 07, 2017

Histone demethylase inhibitors

Applicant:

Celgene Quanticel Research, Inc., San Diego, CA (US);

Inventors:

Toufike Kanouni, Rancho Santa Fe, CA (US);

Zhe Nie, San Diego, CA (US);

Jeffrey Alan Stafford, San Diego, CA (US);

James Marvin Veal, Apex, NC (US);

Assignee:

CELGENE QUANTSCEL RESEARCH, INC., San Diego, CA (US);

Attorney:

Wiley Rein LLP

Primary Examiner:

Patricia L Morris

Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 401/14 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/5377 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/00 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/5377 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01);
Abstract

The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase enzymes. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

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