The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2019
Filed:
Aug. 10, 2016
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Luc Eberhardt, Wiesbaden, DE;
Andreas Waechtler, Darmstadt, DE;
David Maillard, Darmstadt, DE;
Stefan Lehmann, Otzberg, DE;
Assignee:
Merck Patent GmbH, Darmstadt, DE;
Primary Examiner:
Int. Cl.
CPC ...
C07D 217/14 (2006.01); C07B 53/00 (2006.01); B01J 31/12 (2006.01); B01J 31/24 (2006.01); C07D 401/04 (2006.01);
U.S. Cl.
CPC ...
C07D 217/14 (2013.01); B01J 31/122 (2013.01); B01J 31/249 (2013.01); B01J 31/2409 (2013.01); B01J 31/2452 (2013.01); C07B 53/00 (2013.01); C07D 401/04 (2013.01); B01J 2531/0266 (2013.01); B01J 2531/827 (2013.01);
Abstract
The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound and subsequent cyclization.