The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 30, 2019

Filed:

Feb. 03, 2017
Applicant:

Virginia Tech Intellectual Properties Inc., Blacksburg, VA (US);

Inventors:

Rafael V. Davalos, Blacksburg, VA (US);

Paulo A. Garcia, Blacksburg, VA (US);

John H. Rossmeisl, Blacksburg, VA (US);

Assignee:

Other;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61K 35/12 (2015.01); C12N 5/00 (2006.01); C12N 13/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3683 (2013.01); A61K 35/12 (2013.01); A61L 27/3633 (2013.01); A61L 27/3691 (2013.01); C12N 5/0068 (2013.01); C12N 13/00 (2013.01); C12N 2533/90 (2013.01);
Abstract

The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.


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