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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10272153 B1

PDFFull Text
Date of Patent:
Apr. 30, 2019

Filed:

Feb. 05, 2015

Antibody to mucin 4 (muc4) glycopeptide and uses thereof

Applicant:

Medicinal Chemistry Pharmaceuticals, Co., Ltd., Hokkaido, JP;

Inventors:

Shinichiro Nishimura, Hokkaido, JP;

Risho Miyoshi, Hokkaido, JP;

Kentaro Naruchi, Hokkaido, JP;

Masakazu Tanaka, Hokkaido, JP;

Assignee:

MEDICINAL CHEMISTRY PHARMACEUTICALS Co., Ltd., Hokkaido, JP;

Attorneys:

Robert C. Netter, Jr.

Dann, Dorfman, Herrell & Skillman

Primary Examiner:

Nelson B Moseley, II

Int. Cl.
CPC ...
C07K 16/30 (2006.01); A61K 39/395 (2006.01); C07K 9/00 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01); A61K 39/00 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61K 39/0011 (2013.01); C07K 9/00 (2013.01); C07K 16/3092 (2013.01); G01N 33/53 (2013.01); G01N 33/574 (2013.01); G01N 33/57415 (2013.01); G01N 33/57419 (2013.01); G01N 33/57423 (2013.01); G01N 33/57438 (2013.01); G01N 33/57449 (2013.01); G01N 33/57496 (2013.01); A61K 2121/00 (2013.01); C07K 14/47 (2013.01); C07K 2317/34 (2013.01);
Abstract

The present invention provides: an antibody that has specificity for MUC 4 having a sugar chain structure that is expressed at a high level in cancer cells; a glycopeptide that constitutes an antigen that is suitable for producing this antibody; and a new means and method for the diagnosis, prevention, and/or treatment of cancer by means of the aforementioned antibody. The present invention relates to a monoclonal antibody against a glycopeptide. The glycopeptide comprises a human MUC 4 tandem unit peptide having an amino acid sequence represented by SEQ ID NO: 1, and an O-linked sugar chain. The O-linked sugar chain is N-acetylgalactosamine (GalNAc) and binds to threonine, which is the 8th amino acid of the tandem unit peptide. The present invention further includes: a glycopeptide for use in the production of a monoclonal antibody against human MUC 4; a method for detecting MUC 4 in a human body fluid sample; a kit that includes the abovementioned monoclonal antibody; and a pharmaceutical composition for the prevention and/or treatment of malignant tumors that contains the abovementioned monoclonal antibody as an active component.

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