The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 23, 2019

Filed:

Dec. 18, 2015
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Xiaolei Song, Baltimore, MD (US);

Michael McMahon, Columbia, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01V 3/00 (2006.01); G01R 33/56 (2006.01); A61B 5/055 (2006.01); G01R 33/561 (2006.01); A61B 5/00 (2006.01);
U.S. Cl.
CPC ...
G01R 33/5605 (2013.01); A61B 5/055 (2013.01); G01R 33/5616 (2013.01); A61B 5/7257 (2013.01); G01R 33/5601 (2013.01);
Abstract

CEST MR imaging, called Multi-echo Parametric VARiation Saturation (Me-PaVARS) CEST places multiple image readouts in between a series of saturation pulses. The saturation pulse parameters are varied in a designated systematic pattern, which allows the generation of CEST contrast maps by encoding the patterns of signal loss into the images for better discrimination between various CEST imaging agents. The saturation parameter changes include, but are not limited to, saturation amplitude (B), saturation length (t), number of pulses, shape of saturation pulses, amplitude of saturation pulses, saturation offset frequency, or a combination of these variations.


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