The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2019
Filed:
Jun. 14, 2018
Applicant:
University of Georgia Research Foundation, Inc., Athens, GA (US);
Inventors:
Yajun Yan, Bogart, GA (US);
Yuheng Lin, Bogart, GA (US);
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., Athens, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12P 13/22 (2006.01); C12N 9/02 (2006.01); A23K 20/10 (2016.01); A23L 2/52 (2006.01); C12N 9/06 (2006.01); C12N 9/88 (2006.01);
U.S. Cl.
CPC ...
C12P 13/227 (2013.01); A23K 20/10 (2016.05); A23L 2/52 (2013.01); C12N 9/0028 (2013.01); C12N 9/0071 (2013.01); C12N 9/88 (2013.01); C12Y 105/01034 (2013.01); C12Y 114/16001 (2013.01); C12Y 402/01096 (2013.01);
Abstract
5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.