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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10266834 B1

PDFFull Text
Date of Patent:
Apr. 23, 2019

Filed:

Aug. 12, 2016

Recombinant rna particles and methods of producing proteins

Applicant:

Synthetic Genomics, Inc., La Jolla, CA (US);

Inventors:

Robert C. Brown, San Diego, CA (US);

Kurt I. Kamrud, San Diego, CA (US);

Assignee:

Synthetic Genomics, Inc., La Jolla, CA (US);

Attorney:

DLA Piper LLP (US)

Primary Examiner:

Channing S Mahatan

Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/86 (2006.01); C12N 15/81 (2006.01); C12N 15/62 (2006.01); C12N 9/62 (2006.01); A61K 39/00 (2006.01); A61K 39/29 (2006.01); C12N 7/00 (2006.01); C07K 16/10 (2006.01); C07K 14/005 (2006.01); C07K 14/745 (2006.01); C07K 14/435 (2006.01); C12N 9/78 (2006.01);
U.S. Cl.
CPC ...
C12N 15/81 (2013.01); A61K 39/0005 (2013.01); A61K 39/292 (2013.01); C07K 14/005 (2013.01); C07K 14/43509 (2013.01); C07K 14/745 (2013.01); C07K 16/1018 (2013.01); C12N 7/00 (2013.01); C12N 9/62 (2013.01); C12N 9/78 (2013.01); C12N 15/62 (2013.01); C12Y 305/04023 (2013.01); A61K 2039/53 (2013.01); C07K 2317/14 (2013.01); C07K 2317/24 (2013.01); C12N 2720/00021 (2013.01); C12N 2720/00034 (2013.01); C12N 2720/00043 (2013.01);
Abstract

The present invention provides compositions and methods for the production and delivery of recombinant double-stranded RNA molecules (dsRNA) encoding heterologous proteins, which can be useful for various therapeutic purposes as well as for the production of desired proteins. The compositions contain engineered double-stranded RNA particles (dsRPs) that can contain a double-stranded RNA molecule that can be a genome or portion of a genome, which can be enclosed in a capsid or coat protein. The dsRNA molecule also comprises an RNA sub-sequence that encodes a heterologous protein. The dsRPs can be derived from wild-type viral organisms. The delivery of the dsRPs (or DNA or RNA molecules) of the invention to an organism provides for therapeutic benefits as well as for the production of desired proteins.

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