The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2019
Filed:
May. 01, 2017
Applicants:
Eric Hoffman, Kensington, MD (US);
Alyson Fiorillo, Washington, DC (US);
Inventors:
Eric Hoffman, Kensington, MD (US);
Alyson Fiorillo, Washington, DC (US);
Assignee:
Children's National Medical Center, Washington, DC (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 31/573 (2006.01); A61K 31/7088 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/573 (2013.01); A61K 31/7088 (2013.01); A61K 45/06 (2013.01); C12N 15/111 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/30 (2013.01);
Abstract
Agents and methods for increasing dystrophin protein expression in muscle through blocking of specific microRNAs and microRNA binding sites on the dystrophin 3' untranslated region (miR-146a, miRNA-146b, miR-223, miR-320a, miR374a, and miR-382). Methods for increasing the amount of dystrophin useful for effective therapeutic intervention for Becker muscular dystrophy, Duchenne muscular dystrophy, and other disorders where loss of dystrophin from muscle causes pathology.