The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2019
Filed:
Dec. 29, 2015
Mogam Institute for Biomedical Research, Yongin-si, Gyeonggi-do, KR;
Dong-Sik Kim, Yongin-si, KR;
Mi Jung Lee, Yongin-si, KR;
Jae Chan Park, Yongin-si, KR;
Sumin Lee, Yongin-si, KR;
Heechun Kwak, Yongin-si, KR;
SungHo Hwang, Yongin-si, KR;
Hyung-Kwon Lim, Yongin-si, KR;
Kisu Kim, Yongin-si, KR;
Young Seoub Park, Yongin-si, KR;
Junhong Jeong, Yongin-si, KR;
Ki Joon Cho, Yongin-si, KR;
MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, Yongin-si, KR;
Abstract
The present invention relates to an antibody that binds specifically to a tissue factor pathway inhibitor (TFPI), a nucleic acid encoding the antibody, a vector comprising the nucleic acid, a host cell transformed with the vector, a method for producing the antibody, and a pharmaceutical composition for treating hemophilia, which comprises the antibody as an active ingredient. The antibody of the present invention, which binds specifically to TFPI, can activate the extrinsic pathway of blood coagulation by inhibiting TFPI. Thus, the antibody of the present invention can be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease in hemophilia-A or hemophilia-B patients.