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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10266547 B1

PDFFull Text
Date of Patent:
Apr. 23, 2019

Filed:

Sep. 16, 2014

Thieno[2,3-e]indole derivatives as new antitumor agents

Applicant:

Nerviano Medical Sciences S.r.l., Nerviano, IT;

Inventors:

Marina Caldarelli, Milan, IT;

Michele Caruso, Milan, IT;

Paolo Orsini, Legnano, IT;

Assignee:

NERVIANO MEDICAL SCIENCES S.R.L., Nerviano (MI), IT;

Attorney:

Scully, Scott, Murphy & Presser, P.C.

Primary Examiner:

Amanda L Aguirre

Int. Cl.
CPC ...
A61K 31/27 (2006.01); A61K 31/4015 (2006.01); A61K 31/407 (2006.01); A61K 38/06 (2006.01); A61K 45/06 (2006.01); C07D 495/04 (2006.01); C07K 5/097 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); A61K 31/27 (2013.01); A61K 31/407 (2013.01); A61K 31/4015 (2013.01); A61K 38/06 (2013.01); A61K 45/06 (2013.01); C07K 5/0821 (2013.01);
Abstract

The present invention relates to a novel class of alkylating agents comprising a thieno[2,3-e]indole moiety tethered to a DNA-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them. The invention also relates to the use of this novel class of alkylating agents in the preparation of conjugates.

Find Patent Forward Citations

Caldarelli, Marina. (2019). Thieno[2,3-e]indole derivatives as new antitumor agents (U.S. Patent No. 10266547). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10266547

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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