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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10266526 B1

PDFFull Text
Date of Patent:
Apr. 23, 2019

Filed:

Sep. 09, 2015

Substituted 1,2,3-triazoles as smyd inhibitors for treating cancer

Applicant:

Epizyme, Inc., Cambridge, MA (US);

Inventors:

Megan Alene Cloonan Foley, Somerville, MA (US);

Kevin Wayne Kuntz, Woburn, MA (US);

James Edward John Mills, Kent, GB;

Lorna Helen Mitchell, Cambridge, MA (US);

Michael John Munchhof, Salem, CT (US);

Darren Martin Harvey, Acton, MA (US);

Assignee:

EPIZYME, INC., Cambridge, MA (US);

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
A61K 31/4192 (2006.01); C07D 249/04 (2006.01); C07D 451/04 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 231/14 (2006.01); C07D 233/90 (2006.01); C07D 401/12 (2006.01); C07D 241/26 (2006.01); C07D 261/10 (2006.01); C07D 263/34 (2006.01); C07D 275/03 (2006.01); C07D 209/08 (2006.01); C07D 277/56 (2006.01); C07C 271/18 (2006.01); C07D 205/04 (2006.01); C07D 211/34 (2006.01); C07D 237/24 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 413/12 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 451/04 (2013.01); C07C 271/18 (2013.01); C07D 205/04 (2013.01); C07D 209/08 (2013.01); C07D 211/34 (2013.01); C07D 213/81 (2013.01); C07D 213/82 (2013.01); C07D 231/14 (2013.01); C07D 233/90 (2013.01); C07D 237/24 (2013.01); C07D 241/26 (2013.01); C07D 249/04 (2013.01); C07D 261/10 (2013.01); C07D 263/34 (2013.01); C07D 275/03 (2013.01); C07D 277/56 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/12 (2013.01); C07D 417/14 (2013.01);
Abstract

The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

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