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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10266523 B1

PDFFull Text
Date of Patent:
Apr. 23, 2019

Filed:

Mar. 30, 2016

Crystaline forms of n-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-methyl-4'-(trifluoromethoxy) [1,1′-biphenyl]-3-methanamide monophosphate, and process of preparation thereof

Applicant:

Crystal Pharmatech Co., Ltd., Suzhou, Jiangsu, CN;

Inventors:

Minhua Chen, Jiangsu, CN;

Yanfeng Zhang, Suzhou, CN;

Fei Lu, Suzhou, CN;

Xiaoyu Zhang, Suzhou, CN;

Assignee:

CRYSTAL PHARMATECH CO., LTD., Suzhou, CN;

Attorneys:

VLP Law Group LLP

Kent H. Cheng

Primary Examiner:

Brenda L Coleman

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); C07D 413/04 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 413/04 (2013.01); A61K 31/5377 (2013.01); A61P 35/00 (2018.01); C07B 2200/13 (2013.01);
Abstract

The present disclosure relates to novel crystalline forms of N-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-methyl-4'-(trifluoromethoxy) [1,1′-biphenyl]-3-carboxamide monophosphate, and process of preparation thereof. The crystalline form of the monophosphate of a compound of formula (I) has low hygroscopicity, is convenient to store, has better stability than that of diphosphonate in prior art, can avoid the risk of crystal transformation in the development and production of the drug. The preparation method is simple, has low cost, and has important value for further optimization and development of the drug.

Find Patent Forward Citations

Chen, Minhua. (2019). Crystaline forms of n-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-methyl-4'-(trifluoromethoxy) [1,1′-biphenyl]-3-methanamide monophosphate, and process of preparation thereof (U.S. Patent No. 10266523). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10266523

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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