The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 23, 2019

Filed:

Aug. 12, 2015
Applicant:

Convergent R.n.r Ltd, Tirat Carmel, IL;

Inventors:

Zeev Harel, Kfar Saba, IL;

Zeev Burshtein, Nes-Ziona, IL;

Aharon Bar-David, Nesher, IL;

Miri Markovich, Haifa, IL;

Assignee:

CONVERGENT R.N.R LTD, Tirat Carmel, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61M 37/00 (2006.01); A61N 5/10 (2006.01); A61K 41/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61M 37/00 (2013.01); A61K 9/0009 (2013.01); A61K 41/00 (2013.01); A61K 41/0052 (2013.01); A61N 5/10 (2013.01); A61M 2037/0007 (2013.01); A61N 2005/1091 (2013.01); A61N 2005/1098 (2013.01);
Abstract

The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.


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