The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 23, 2019

Filed:

Mar. 10, 2017
Applicant:

Pioneer Surgical Technology, Inc., Marquette, MI (US);

Inventors:

Francis Vincent Lamberti, Cary, NC (US);

Richard Chris Klann, Washington, NC (US);

Ronald Stewart Hill, Greenville, NC (US);

Assignee:

Pioneer Surgical Technology, Inc., Marquette, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/20 (2006.01); A61L 27/22 (2006.01); A61L 27/26 (2006.01); A61L 27/34 (2006.01); A61L 27/52 (2006.01); A61L 31/10 (2006.01); A61L 27/02 (2006.01); A61L 27/12 (2006.01); A61L 27/36 (2006.01); A61F 2/00 (2006.01); A61K 47/42 (2017.01); A61L 27/24 (2006.01); A61L 27/54 (2006.01); B29C 39/00 (2006.01); A61L 27/44 (2006.01); A61L 27/46 (2006.01); B29L 31/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/222 (2013.01); A61F 2/0063 (2013.01); A61K 47/42 (2013.01); A61L 27/025 (2013.01); A61L 27/12 (2013.01); A61L 27/20 (2013.01); A61L 27/22 (2013.01); A61L 27/24 (2013.01); A61L 27/26 (2013.01); A61L 27/34 (2013.01); A61L 27/3608 (2013.01); A61L 27/446 (2013.01); A61L 27/46 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 31/10 (2013.01); B29C 39/003 (2013.01); A61L 2300/112 (2013.01); A61L 2300/412 (2013.01); A61L 2420/04 (2013.01); A61L 2420/06 (2013.01); A61L 2430/02 (2013.01); B29L 2031/7532 (2013.01); Y10T 428/29 (2015.01); Y10T 428/2947 (2015.01); Y10T 428/31551 (2015.04); Y10T 428/31786 (2015.04);
Abstract

The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.


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