The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2019
Filed:
Aug. 11, 2016
Applicant:
Bergen Teknologioverføring As, Bergen, NO;
Inventors:
Aurora Martinez, Eidsvågneset, NO;
Oscar Aubi Catevilla, Bergen, NO;
Lars Skjærven, Bergen, NO;
Jarl Underhaug, Bergen, NO;
Ming Ying, Bergen, NO;
Knut Teigen, Bergen, NO;
Assignee:
BERGEN TEKNOLOGIOVERFØRING AS, Bergen, NO;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61P 3/00 (2006.01); A61K 31/506 (2006.01); A61K 31/522 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/44 (2013.01); A61K 31/506 (2013.01); A61K 31/522 (2013.01); A61P 3/00 (2018.01); A61K 45/06 (2013.01); A61K 2300/00 (2013.01);
Abstract
The present invention relates to compounds of formula (I) as defined in the specification for use as pharmacological chaperones having a stabilizing effect on phenylalanine hydroxylase (PAH) for the treatment of hyperphenylalaninemia (HPA), in particular phenylketonuria (PKU). The compounds include trimethoprim and analogues and derivatives thereof.