The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2019
Filed:
Jul. 17, 2014
Applicant:
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Inventors:
Assignee:
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 31/203 (2006.01); A61K 45/06 (2006.01); A61K 31/436 (2006.01); A61K 31/11 (2006.01); A61K 31/232 (2006.01); A61K 31/337 (2006.01); A61K 31/4418 (2006.01); A61K 31/475 (2006.01); A61K 31/704 (2006.01); A61K 31/7064 (2006.01);
U.S. Cl.
CPC ...
A61K 31/203 (2013.01); A61K 31/11 (2013.01); A61K 31/232 (2013.01); A61K 31/337 (2013.01); A61K 31/436 (2013.01); A61K 31/4418 (2013.01); A61K 31/475 (2013.01); A61K 31/704 (2013.01); A61K 31/7064 (2013.01); A61K 45/06 (2013.01);
Abstract
The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors.