Glutathione-detecting fluorescent probe

Abstract

[Problem] To provide the following: a novel fluorescent probe for detecting a compound, such as glutathione, that contains a —SH group; a detection method using said fluorescent probe; and a detection kit containing said probe. [Solution] A fluorescent probe for detecting a compound containing an —SH group, wherein the fluorescent probe comprises a compound represented by formula (I) or a salt thereof (In the formula, X represents Si(R)(R), Ge(R)(R), Sn(R)(R), C(R)(R), or O (wherein Rand Reach independently represent a hydrogen atom or alkyl group); Rrepresents a hydrogen atom, or 1-4 identical or different substituents independently selected from the group consisting of a cyano group, alkyl group, carboxyl group, ester group, alkoxy group, amide group, and azide group, each of which may be optionally substituted; Rrepresents a hydrogen atom, halogen atom, hydroxyl group, cyano group, or an alkyl group, alkynyl group, alkoxy group, aryl, or heteroaryl, each of which may be optionally substituted; Rand Reach independently represent a hydrogen atom or 1-3 identical or different substituents independently selected from the group consisting of a hydroxyl group, halogen atom, or an alkyl group, sulfo group, carboxyl group, ester group, amide group and azide group, each of which may be optionally substituted; R, R, Rand Reach independently represent a hydrogen atom or alkyl group, wherein, Ror R, respectively together with R, may form a ring structure including the nitrogen atoms bonded thereto, or Ror R, respectively together with R, may form a ring structure including the nitrogen atoms bonded thereto).