The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 16, 2019

Filed:

Feb. 20, 2012
Applicants:

Abraham Lee, Irvine, CA (US);

Philip Felgner, Rancho Santa Fe, CA (US);

Armando Tovar, Newport Beach, CA (US);

Uland Liao, Irvine, CA (US);

Inventors:

Abraham Lee, Irvine, CA (US);

Philip Felgner, Rancho Santa Fe, CA (US);

Armando Tovar, Newport Beach, CA (US);

Uland Liao, Irvine, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 60/12 (2006.01); B01L 3/00 (2006.01); G01N 21/05 (2006.01); G01N 21/78 (2006.01); G01N 21/82 (2006.01); G01N 33/543 (2006.01); G01N 33/58 (2006.01); G01N 33/68 (2006.01); G01N 21/77 (2006.01); G01N 21/03 (2006.01);
U.S. Cl.
CPC ...
C40B 60/12 (2013.01); B01L 3/502715 (2013.01); G01N 21/05 (2013.01); G01N 21/78 (2013.01); G01N 21/82 (2013.01); G01N 33/54366 (2013.01); G01N 33/581 (2013.01); G01N 33/6803 (2013.01); G01N 33/6845 (2013.01); B01J 2219/0061 (2013.01); B01J 2219/00315 (2013.01); B01J 2219/00479 (2013.01); B01J 2219/00531 (2013.01); B01J 2219/00608 (2013.01); B01J 2219/00612 (2013.01); B01J 2219/00617 (2013.01); B01J 2219/00621 (2013.01); B01J 2219/00626 (2013.01); B01J 2219/00635 (2013.01); B01J 2219/00637 (2013.01); B01L 2300/0654 (2013.01); G01N 2021/0346 (2013.01); G01N 2021/054 (2013.01); G01N 2021/058 (2013.01); G01N 2021/7763 (2013.01); G01N 2021/7773 (2013.01); G01N 2021/825 (2013.01); Y02A 50/394 (2018.01); Y02A 50/412 (2018.01); Y02A 50/58 (2018.01);
Abstract

Contemplated microfluidic devices and methods are drawn to protein arrays in which distinct and detergent-containing antigen preparations are deposited onto an optical contrast layer in a non-specific and non-covalent manner. Detection of binding a is carried out using a dye that precipitates or agglomerates to so form a visually detectable signal at a dynamic range of at least three orders of magnitude.


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