The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 16, 2019

Filed:

May. 29, 2015
Applicant:

Novogy, Inc., Cambridge, MA (US);

Inventors:

Vasiliki Tsakraklides, Lexington, MA (US);

Elena E. Brevnova, Belmont, MA (US);

Assignee:

Novogy, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 7/64 (2006.01); C12N 9/10 (2006.01); C12N 9/20 (2006.01);
U.S. Cl.
CPC ...
C12P 7/6463 (2013.01); C12N 9/1025 (2013.01); C12N 9/1029 (2013.01); C12N 9/20 (2013.01); C12Y 203/0102 (2013.01); C12Y 301/01003 (2013.01);
Abstract

Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by increasing the activity of a type 1 diacylglycerol acyltransferase (i.e., DGA2) and increasing the activity of a type 2 diacylglycerol acyltransferase (i.e., DGA1). In some embodiments, the triacylglycerol content of a cell is also modified by decreasing the activity of a triacylglycerol lipase in the same cell. Also disclosed are methods and compositions for increasing the triacylglycerol content of a cell by increasing the activity of a type 1 diacylglycerol acyltransferase (i.e., DGA2), or by increasing the activity of a type 3 diacylglycerol acyltransferase (i.e., DGA3).


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