The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 16, 2019

Filed:

Nov. 10, 2017
Applicants:

President and Fellows of Harvard College, Cambridge, MA (US);

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Quan Lu, Newton, MA (US);

Qiyu Wang, Boston, MA (US);

Stanley N. Cohen, Palo Alto, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); C12N 9/16 (2006.01); C12N 9/22 (2006.01); C12N 15/87 (2006.01); C12N 9/00 (2006.01); A61K 47/64 (2017.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); A61K 47/6455 (2017.08); C07K 7/06 (2013.01); C07K 14/4718 (2013.01); C12N 9/22 (2013.01); C12N 9/93 (2013.01); A61K 9/1272 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/03 (2013.01); C07K 2319/70 (2013.01); C07K 2319/85 (2013.01); C12N 2810/85 (2013.01);
Abstract

Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of cargo proteins, such as transcription factors, tumor suppressors, developmental regulators, growth factors, metastasis suppressors, pro-apoptotic proteins, nucleases, recombinases, and reprogramming factors into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.


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