The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2019
Filed:
Mar. 08, 2013
Universitätsklinikum Freiburg, Freiburg, DE;
Albert-ludwigs-univesität Freiburg, Freiburg, DE;
Karen Lienkamp, Gundelfingen, DE;
Jakob Belardi, Nürnberg, DE;
Peng Zou, Freiburg, DE;
Ali Al-Ahmad, Freiburg, DE;
Thorsten Steinberg, Mannheim, DE;
Pascal Tomakidi, Freiburg, DE;
UNIVERSITATSKLINIKUM FREIBURG, Freiburg, DE;
ALBERT-LUDWIGS-UNIVERSITAT FREIBURG, Freiburg, DE;
Abstract
The present invention relates to substrates comprising a crosslinked network of covalently attached antimicrobial and/or antibiofouling polymers. The crosslinked network of antimicrobial and/or antibiofouling polymers acts highly efficiently against pathogens, e.g. bacteria and fungi. Both the antimicrobial and the antibiofouling cross-linked polymer networks are preferably better resistant to mechanical damage than simple surface-immobilized polymer monolayers. The antimicrobial and/or antibiofouling polymers of the crosslinked network are preferably obtained by ring opening metathesis polymerization (ROMP) and exhibit a molecular weight of preferably more than 30,000 or even 100,000 g mol. The crosslinked network of antimicrobial and/or antibiofouling polymers is preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. The present invention is also directed to uses of crosslinked networks of antimicrobial and/or antibiofouling polymers as defined herein, e.g. for coating a surface of a substrate, and to methods therefore.