The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2019
Filed:
Jun. 03, 2016
Lead Pharma Holding B.v., Nijmegen, NL;
Sanofi, Paris, FR;
Joseph Maria Gerardus Barbara Cals, Oss, NL;
Vera De Kimpe, Oss, NL;
Sander Bernardus Nabuurs, Oss, NL;
Cosimo Damiano Cadicamo, Oss, NL;
Jaap Gerardus Henricus Lemmers, Oss, NL;
LEAD PHARMA HOLDING B.V., Nijmegen, NL;
SANOFI, Paris, FR;
Abstract
Compounds according to Formula I: or a pharmaceutically acceptable salt thereof wherein: Ais NRor CR, with Rbeing H or methyl, with methyl, if present, optionally being substituted with one or more F; the cyclopropyl moiety can be optionally substituted with one or more methyl and one or more F; A-Aare N or CR-CR, respectively, with the proviso that no more than two of the four positions A in A-Acan be simultaneously N; R-Rare independently H, halogen, amino, C(1-3)alkoxy, (di)C(1-3)alkylamino or C(1-6)alkyl; Rand Rare independently H, F, methyl, ethyl, hydroxyl or methoxy or Rand Rtogether is carbonyl, all alkyl groups, if present, optionally being substituted with one or more F; Ris H or C(1-6)alkyl; Ris selected from the group consisting of Formula II, III, IV and V The compounds can be used as inhibitors of RORγ and are useful for the treatment of RORγ mediated diseases.