The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 16, 2019

Filed:

Dec. 01, 2014
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Brent R. Stockwell, New York, NY (US);

Rachid Skouta, New York, NY (US);

Scott Dixon, New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 229/56 (2006.01); A61K 31/245 (2006.01); A61K 45/06 (2006.01); A61K 31/196 (2006.01); A61K 31/505 (2006.01); C07C 255/58 (2006.01); C07C 271/24 (2006.01); C07C 229/60 (2006.01); C07D 401/12 (2006.01); C07D 239/26 (2006.01); C07D 213/38 (2006.01);
U.S. Cl.
CPC ...
C07C 229/56 (2013.01); A61K 31/196 (2013.01); A61K 31/245 (2013.01); A61K 31/505 (2013.01); A61K 45/06 (2013.01); C07C 229/60 (2013.01); C07C 255/58 (2013.01); C07C 271/24 (2013.01); C07D 213/38 (2013.01); C07D 239/26 (2013.01); C07D 401/12 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2601/18 (2017.05); C07C 2601/20 (2017.05); C07C 2603/72 (2017.05); C07C 2603/74 (2017.05);
Abstract

The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.


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