The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 16, 2019

Filed:

Mar. 14, 2014
Applicant:

Modernatx, Inc., Cambridge, MA (US);

Inventors:

Stephen G. Hoge, Brookline, MA (US);

Örn Almarsson, Shrewsbury, MA (US);

David D. Hile, Westborough, MA (US);

Ciarán Lawlor, Cambridge, MA (US);

John Podobinski, Boston, MA (US);

Staci Sabnis, Somerville, MA (US);

Antonin de Fougerolles, Waterloo, BE;

Divakar Ramakrishnan, Lexington, MA (US);

Kristy M. Wood, Wellesley, MA (US);

Assignee:

ModernaTX, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/7105 (2006.01); C12Q 1/68 (2018.01); C12N 15/87 (2006.01); C12N 15/88 (2006.01); A61K 47/52 (2017.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 47/52 (2017.08); A61K 48/005 (2013.01); A61K 48/0075 (2013.01); C12N 15/87 (2013.01); C12N 15/88 (2013.01);
Abstract

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.


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