IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10258626 B1

PDFFull Text
Date of Patent:
Apr. 16, 2019

Filed:

Feb. 09, 2017

Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them

Applicants:

Les Laboratoires Servier, Suresnes, FR;

Vernalis (R&d) Ltd, Winnersh, GB;

Inventors:

Thierry Le Diguarher, Saint Denis de l'Hôtel, FR;

Patrick Casara, Strasbourg, FR;

Jérôme-Benoît Starck, Rueil-Malmaison, FR;

Jean-Michel Henlin, Suresnes, FR;

James Edward Paul Davidson, Great Shelford, GB;

James Brooke Murray, Linton, GB;

Christopher John Graham, Newmarket, GB;

I-Jen Chen, Cambridge, GB;

Olivier Geneste, Rueil-Malmaison, FR;

John Hickman, Paris, FR;

Stéphane Depil, Issy les Moulineaux, FR;

Arnaud Le Tiran, Croissy sur Seine, FR;

Mikl{dot over (o)}s Nyerges, Le{dot over (a)}nyfalu, HU;

Guillaume De Nanteuil, Suresnes, FR;

Assignees:

LES LABORATORIES SERVIER, Suresnes, FR;

VERNALIS (R&D) LTD, Winnersh Berkshire, GB;

Attorney:

Hueschen and Sage

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
A61K 31/55 (2006.01); A61K 31/475 (2006.01); A61K 31/496 (2006.01); A61K 31/541 (2006.01); A61K 31/553 (2006.01); A61K 31/4725 (2006.01); A61K 31/5377 (2006.01); A61K 31/5383 (2006.01); C07D 491/052 (2006.01); C07D 401/02 (2006.01); C07D 401/12 (2006.01); A61N 5/10 (2006.01); C07D 471/00 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 207/30 (2006.01); C07D 211/06 (2006.01); C07D 211/80 (2006.01); A61K 45/06 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/475 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/5383 (2013.01); A61K 31/541 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); A61N 5/1001 (2013.01); C07D 207/30 (2013.01); C07D 211/06 (2013.01); C07D 211/80 (2013.01); C07D 471/00 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 491/052 (2013.01); C07D 498/04 (2013.01);
Abstract

Compounds of formula (I): wherein R, R, R, R, R, R, R, R, R, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

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