The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2019
Filed:
May. 24, 2012
Robert J. Gillies, Tampa, FL (US);
David L. Morse, Tampa, FL (US);
Ariosto Siqueira Silva, Tampa, FL (US);
Arig A. Ibrahim Hashim, Tampa, FL (US);
Robert A. Gatenby, Tampa, FL (US);
Gary Martinez, Tampa, FL (US);
Robert J. Gillies, Tampa, FL (US);
David L. Morse, Tampa, FL (US);
Ariosto Siqueira Silva, Tampa, FL (US);
Arig A. Ibrahim Hashim, Tampa, FL (US);
Robert A. Gatenby, Tampa, FL (US);
Gary Martinez, Tampa, FL (US);
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Abstract
A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.